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DOSAGE AND ADMINISTRATION
Firstly, for patients with breast cancer, the recommended daily dose is 20-40 mg.buy nolvadex
In three single agent adjuvant studies in women, one 10 mg NOLVADEX (tamoxifen citrate) tablet was administered two (ECOG and NATO) or three (Toronto) times a day for two years. In the NSABP B-14 adjuvant study in women with node-negative breast cancer. We can use one 10 mg NOLVADEX (tamoxifen citrate) tablet twice a day for at least 5 years. Results of the B-14 study suggest that continuation of therapy beyond five years does not provide additional benefit (see CLINICAL PHARMACOLOGY). In the EBCTCG 1995 overview, the reduction in recurrence and mortality was greater in those studies that used tamoxifen for about 5 years than in those that used tamoxifen for a shorter period of therapy. There was no indication that doses greater than 20 mg per day were more effective. Current data from clinical trials support 5 years of adjuvant NOLVADEX (tamoxifen citrate) therapy for patients with breast cancer.
Ductal Carcinoma in Situ (DCIS)
The recommended dose is NOLVADEX (tamoxifen citrate) 20 mg daily for 5 years.
Reduction in Breast Cancer Incidence in High Risk Women
The recommended dose is NOLVADEX (tamoxifen citrate) 20 mg daily for 5 years. Also, there are no data to support the use of NOLVADEX (tamoxifen citrate) other than for 5 years (See CLINICAL PHARMACOLOGY-Clinical Studies – Reduction in Breast Cancer Incidence in High Risk Women).
10 mg Tablets containing tamoxifen as the citrate in an amount equivalent to 10 mg of tamoxifen. (round, biconvex, uncoated, white tablet identified with NOLVADEX (tamoxifen citrate). 600 debossed on one side and a cameo debossed on the other side) is in bottles of 60 tablets. NDC 0310-0600-60.
20 mg Tablets containing tamoxifen as the citrate in an amount equivalent to 20 mg of tamoxifen. (round, biconvex, uncoated, white tablet identified with NOLVADEX (tamoxifen citrate) 604 debossed on one side. And a cameo debossed on the other side) is in bottles of 30 tablets. NDC 0310-0604-30.
Metastatic Breast Cancer
Firstly, Increased bone and tumor pain and, also, local disease flare have occurred, which are sometimes associated with a good tumor response. In adition, patients with increased bone pain may require additional analgesics. Furthermore, patients with soft tissue disease may have sudden increases in the size of preexisting lesions, sometimes associated with marked erythema within and surrounding the lesions and/or the development of new lesions. Also, when they occur, the bone pain or disease we notice a flare shortly after starting NOLVADEX (tamoxifen citrate). And generally subside rapidly.
In patients treated with NOLVADEX (tamoxifen citrate) for metastatic breast cancer, the most frequent adverse reaction to NOLVADEX (tamoxifen citrate) is hot flashes.
To conclue, other adverse reactions which are seen infrequently are hypercalcemia, peripheral edema, distaste for food, pruritus vulvae, depression, dizziness, light-headedness, headache, hair thinning and/or partial hair loss, and vaginal dryness.